Identifiers: city · CDP · town
| Rank | Community | Population |
|---|---|---|
| 1 | Port St. Lucie (city), FL | 204,851 |
| 2 | Fort Pierce (city), FL | 47,297 |
| 3 | Vero Beach South (CDP), FL | 28,020 |
| 4 | Palm City (CDP), FL | 25,883 |
| 5 | Florida Ridge (CDP), FL | 21,302 |
| 6 | Stuart (city), FL | 17,425 |
| 7 | Jensen Beach (CDP), FL | 12,652 |
| 8 | Lakewood Park (CDP), FL | 12,510 |
| 9 | West Vero Corridor (CDP), FL | 10,039 |
| 10 | Fort Pierce North (CDP), FL | 6,904 |
| 11 | Indian River Estates (CDP), FL | 6,584 |
| 12 | River Park (CDP), FL | 6,514 |
| 13 | Fort Pierce South (CDP), FL | 5,209 |
| 14 | White City (CDP), FL | 3,779 |
| 15 | North River Shores (CDP), FL | 3,459 |
| 16 | Rio (CDP), FL | 980 |
| 17 | St. Lucie Village (town), FL | 613 |
| 18 | Ocean Breeze (town), FL | 301 |