Identifiers: city · CDP
| Rank | Community | Population |
|---|---|---|
| 1 | Poplar Bluff (city), MO | 16,225 |
| 2 | Dexter (city), MO | 7,927 |
| 3 | Fairdealing (CDP), MO | 543 |
| 4 | Qulin (city), MO | 460 |
| 5 | Ellsinore (city), MO | 416 |
| 6 | Neelyville (city), MO | 318 |
| 7 | Fisk (city), MO | 312 |
| 8 | Williamsville (city), MO | 279 |
| 9 | Broseley (CDP), MO | 163 |
| 10 | Dudley (city), MO | 101 |
| 11 | Harviell (CDP), MO | 98 |