Identifiers: city · CDP · town
| Rank | Community | Population |
|---|---|---|
| 1 | Anderson (city), SC | 28,106 |
| 2 | Clemson (city), SC | 17,681 |
| 3 | Gantt (CDP), SC | 15,006 |
| 4 | Powdersville (CDP), SC | 10,025 |
| 5 | Clemson University (CDP), SC | 7,311 |
| 6 | Centerville (CDP), SC | 7,185 |
| 7 | Homeland Park (CDP), SC | 6,445 |
| 8 | Piedmont (CDP), SC | 5,411 |
| 9 | Belton (city), SC | 4,335 |
| 10 | Williamston (town), SC | 4,043 |
| 11 | Northlake (CDP), SC | 3,818 |
| 12 | Dunean (CDP), SC | 3,740 |
| 13 | Pendleton (town), SC | 3,489 |
| 14 | Golden Grove (CDP), SC | 3,002 |
| 15 | Judson (CDP), SC | 2,352 |
| 16 | Pelzer (town), SC | 1,344 |
| 17 | Iva (town), SC | 1,015 |
| 18 | Sandy Springs (CDP), SC | 1,002 |
| 19 | West Pelzer (town), SC | 962 |
| 20 | Fair Play (CDP), SC | 704 |