Identifiers: city · CDP · town
| Rank | Community | Population |
|---|---|---|
| 1 | Orangeburg (city), SC | 13,240 |
| 2 | Brookdale (CDP), SC | 3,845 |
| 3 | Denmark (city), SC | 3,186 |
| 4 | Bamberg (town), SC | 3,076 |
| 5 | Allendale (town), SC | 2,694 |
| 6 | Edisto (CDP), SC | 2,058 |
| 7 | Wilkinson Heights (CDP), SC | 1,946 |
| 8 | Branchville (town), SC | 998 |
| 9 | Ehrhardt (town), SC | 457 |
| 10 | Hilda (town), SC | 418 |
| 11 | Neeses (town), SC | 320 |
| 12 | Norway (town), SC | 289 |
| 13 | Rowesville (town), SC | 253 |
| 14 | Olar (town), SC | 215 |
| 15 | Sycamore (town), SC | 147 |
| 16 | Cordova (town), SC | 136 |
| 17 | Livingston (town), SC | 132 |
| 18 | Lodge (town), SC | 82 |
| 19 | Ulmer (town), SC | 65 |
| 20 | Govan (town), SC | 56 |