Identifiers: town · city · CDP
| Rank | Community | Population |
|---|---|---|
| 1 | Port Royal (town), SC | 14,220 |
| 2 | Beaufort (city), SC | 13,607 |
| 3 | Burton (CDP), SC | 6,777 |
| 4 | Laurel Bay (CDP), SC | 5,082 |
| 5 | Seabrook (CDP), SC | 1,255 |
| 6 | Fripp Island (CDP), SC | 963 |
| 7 | Dale (CDP), SC | 633 |
| 8 | Sheldon (CDP), SC | 579 |
| 9 | Lobeco (CDP), SC | 292 |
| 10 | Harbor Island (CDP), SC | 209 |