Identifiers: town · CDP · city
| Rank | Community | Population |
|---|---|---|
| 1 | Lexington (town), SC | 23,568 |
| 2 | St. Andrews (CDP), SC | 20,675 |
| 3 | West Columbia (city), SC | 17,416 |
| 4 | Seven Oaks (CDP), SC | 14,652 |
| 5 | Dentsville (CDP), SC | 14,431 |
| 6 | Cayce (city), SC | 13,781 |
| 7 | Oak Grove (CDP), SC | 12,899 |
| 8 | Irmo (town), SC | 11,569 |
| 9 | Red Bank (CDP), SC | 10,924 |
| 10 | Newberry (city), SC | 10,691 |
| 11 | Forest Acres (city), SC | 10,617 |
| 12 | Woodfield (CDP), SC | 9,199 |
| 13 | Lake Murray of Richland (CDP), SC | 8,110 |
| 14 | Springdale (town), SC | 2,744 |
| 15 | South Congaree (town), SC | 2,377 |
| 16 | Arthurtown (CDP), SC | 2,294 |
| 17 | Pine Ridge (town), SC | 2,167 |
| 18 | Chapin (town), SC | 1,809 |
| 19 | Gaston (town), SC | 1,608 |
| 20 | Prosperity (town), SC | 1,178 |