Identifiers: city · CDP · town
| Rank | Community | Population |
|---|---|---|
| 1 | Hartsville (city), SC | 7,446 |
| 2 | East Camden (CDP), SC | 3,215 |
| 3 | North Hartsville (CDP), SC | 2,775 |
| 4 | Pageland (town), SC | 2,456 |
| 5 | Pine Ridge (CDP), SC | 807 |
| 6 | Jefferson (town), SC | 772 |
| 7 | McBee (town), SC | 758 |
| 8 | Lydia (CDP), SC | 572 |
| 9 | Bethune (town), SC | 315 |
| 10 | Patrick (town), SC | 266 |
| 11 | Abney Crossroads (CDP), SC | 101 |