Identifiers: city · town · CDP
| Rank | Community | Population |
|---|---|---|
| 1 | Sioux Falls (city), SD | 192,517 |
| 2 | Brandon (city), SD | 11,048 |
| 3 | Harrisburg (city), SD | 6,732 |
| 4 | Tea (city), SD | 5,598 |
| 5 | Dell Rapids (city), SD | 3,996 |
| 6 | Hartford (city), SD | 3,354 |
| 7 | Crooks (city), SD | 1,362 |
| 8 | Salem (city), SD | 1,325 |
| 9 | Baltic (city), SD | 1,246 |
| 10 | Worthing (city), SD | 927 |
| 11 | Valley Springs (city), SD | 885 |
| 12 | Colton (city), SD | 738 |
| 13 | Canistota (city), SD | 631 |
| 14 | Humboldt (town), SD | 579 |
| 15 | Meadow View Addition (CDP), SD | 531 |
| 16 | Montrose (city), SD | 468 |
| 17 | Renner Corner (CDP), SD | 347 |
| 18 | Pine Lakes Addition (CDP), SD | 306 |
| 19 | Lyons (CDP), SD | 70 |
| 20 | Rowena (CDP), SD | 68 |