Identifiers: city · town · CDP
| Rank | Community | Population |
|---|---|---|
| 1 | Yankton (city), SD | 15,411 |
| 2 | Vermillion (city), SD | 11,695 |
| 3 | North Sioux City (city), SD | 3,042 |
| 4 | Beresford (city), SD | 2,180 |
| 5 | Elk Point (city), SD | 2,149 |
| 6 | Centerville (city), SD | 918 |
| 7 | Jefferson (city), SD | 475 |
| 8 | Gayville (town), SD | 382 |
| 9 | Wakonda (town), SD | 347 |
| 10 | Mission Hill (town), SD | 190 |
| 11 | Volin (town), SD | 158 |
| 12 | Richland (CDP), SD | 97 |
| 13 | Burbank (CDP), SD | 93 |
| 14 | Meckling (CDP), SD | 48 |