Identifiers: city · town · CDP
| Rank | Community | Population |
|---|---|---|
| 1 | Yankton (city), SD | 15,411 |
| 2 | Irene (city), SD | 422 |
| 3 | Tabor (town), SD | 407 |
| 4 | Gayville (town), SD | 382 |
| 5 | Mission Hill (town), SD | 190 |
| 6 | Volin (town), SD | 158 |
| 7 | Lesterville (town), SD | 115 |
| 8 | Jamesville Colony (CDP), SD | 110 |
| 9 | Utica (town), SD | 70 |
| 10 | Meckling (CDP), SD | 48 |